The fat cells in our bodies have receptor sites where HGH and IGF-1 may bind to the cell. Once attached, HGH and IGF-1 set up a series of reactions in the cell's biochemistry, the end result of which is the breakdown in fat. You might look at HGH as the crank that came with the old Model T Ford. The crank, when put in place to where it hooked up to the motor, could be turned quickly, causing the engine to turn over and start, burning fuel in the cylinders to provide energy and motive power to the car.

So too, when HGH attaches to a fat cell: it cranks the cell into starting the reactions which bring about the breakdown of fat, a process called lypolysis. When the fat is broken down in the body it may then serve as fuel to be burned by the body, providing energy and motive power.

Another explanation concerning a different operation of HGH was put forth by Dr. Rudman and colleagues. This hypothesis looked at HGH as something of an insulin "blocker" in fat cell production. While insulin acts to promote lypogenesis, the creation of fat in fat cells, Rudman theorizes that HGH promotes typolysis, the destruction of fat in fat cells. In this model, insulin works on a cell so as to promote the entry of amino acids, glucose, and fats. In opposition to this, HGH works to block insulin in this function, keeping the fat cells from growing larger.

Diabetes Type 2 is becoming endemic in North America, with estimates of up to 10% of the population affected.
Its rise in the 30-40 age group coincides with the obesity and poor dietary habits seen in America today.

Given these figures, the importance of HGH as an agent in bringing about fat loss is once again underscored.
And no matter how the details of the physiology of HGH come to be understood ultimately,
the conclusion that HGH does bring about fat loss is uncontested.